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目的研究血清胱抑素C(CysC)和同型半胱氨酸(Hcy)在早期糖尿病肾病诊断中的应用价值。方法选取新乡医学院第三附属医院内分泌科在2015年1月至2016年2月收治的100例糖尿病患者,再根据患者尿微量清蛋白排泄率,将患者分为单纯糖尿病组与早期糖尿病肾病组,每组50例;另外选取50例来新乡医学院第三附属医院作健康体检的健康居民作为对照组。检测并比较三组被检者血清CysC和Hcy水平。结果早期糖尿病肾病组血清CysC和Hcy水平明显高于单纯糖尿病组与对照组(P<0.05);单纯糖尿病组血清CysC和Hcy水平高于对照组(P<0.05);单项检测早期糖尿病肾病组的血清CysC和Hcy的阳性表达率明显低于联合检测CysC+Hcy阳性检测率(P<0.05)。结论血清CysC和Hcy水平的单一检测对早期糖尿病肾病患者有一定的应用诊断价值,但二者联合检测的阳性表达率更高,对早期糖尿病肾病的诊断价值更大。
Objective To study the value of serum cystatin C (CysC) and homocysteine (Hcy) in the diagnosis of early diabetic nephropathy. Methods One hundred patients with diabetes who were treated in Department of Endocrinology of the Third Affiliated Hospital of Xinxiang Medical College from January 2015 to February 2016 were selected and divided into simple diabetic group and early diabetic nephropathy group according to urinary albumin excretion rate , 50 cases in each group. In addition, 50 healthy people from the Third Affiliated Hospital of Xinxiang Medical College were selected as the control group. The levels of serum CysC and Hcy in the three groups were detected and compared. Results Serum levels of CysC and Hcy in early diabetic nephropathy group were significantly higher than those in simple diabetic group and control group (P <0.05). Serum levels of CysC and Hcy in diabetic group were significantly higher than those in control group (P <0.05) The positive rates of CysC and Hcy in serum were significantly lower than those of CysC + Hcy (P <0.05). Conclusion The single detection of serum CysC and Hcy levels may be useful in the diagnosis of patients with early diabetic nephropathy. However, the combined detection of CysC and Hcy may have a higher positive rate and a higher diagnostic value for early diabetic nephropathy.