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经腹羊水穿刺术是一种对母亲和胎儿危险性低及诊断准确度高的产前遗传学诊断的方法。然而其主要的缺点是在中期妊娠之前不能施行,因此在妊娠18周以前很少能了解胎儿的核型。为此,早期妊娠产前诊断的技术开发对孕妇及其家庭有明显利益。几乎20年前(Hahnemann 和 Mobr,1968,1969)已报告在早期妊娠通过宫颈取绒毛标本(CVS)进行绒毛细胞培养的实验性研究,并在1968年 Hahnemann 和 Mohr 实现了应用CVS 作产前细胞遗传学诊断的可能性。然而,仅在1983年初,对早期妊娠细胞遗传学诊断才发生了突破性进展;即在超声指导下经官
Transabdominal amniocentesis is a method of prenatal genetic diagnosis of low maternal and fetal risk and high diagnostic accuracy. However, its main drawback is that it can not be administered until the second trimester, so it is rare to know the fetal karyotype until 18 weeks of gestation. For this reason, the technical development of prenatal diagnosis of early pregnancy has obvious benefits for pregnant women and their families. Almost 20 years ago (Hahnemann and Mobr, 1968, 1969) reported experimental studies of villus cell culture in early pregnancy through the Cervical Capture Villus (CVS) and in 1968 Hahnemann and Mohr achieved the use of CVS for prenatal cells Genetic diagnosis of the possibility. However, only in early 1983 did breakthrough advances in cytogenetic diagnosis of early gestational pregnancies occurred; under the guidance of ultrasound,