寻求疟疾的病因性预防药物是疟疾防治工作中十分重要的课题。疟疾的病因性预防是指“使用这些药物能杀灭侵入人体的于孢子或杀灭疟原虫红细胞前期,从而完全防止人体红细胞受到疟原虫感染”,因而较抑制性预防有明显的优点。对此,疟疾学家们在过去长时间内进行了不少研究,但是结果并不令人满意。到目前为止,仅有伯氨喹啉、乙胺嘧啶和氯胍(包括环氯胍)对人疟有病因性预防作用。但是,伯喹毒性太大,不能用于 Seeking malaria etiology preventive medicine is a very important issue in malaria prevention and control work. The etiological prevention of malaria refers to “the use of these drugs can kill the spores invade the body or kill the pre-erythrocytic stage of malaria parasite, thereby completely preventing human red blood cells infected with Plasmodium”, and thus have obvious advantages compared with prophylactic prevention. In this regard, malaria scientists in the past a long time a lot of research, but the result is not satisfactory. To date, only primaquine, pyrimethamine and proguanil (including cycloguanidine) have etiological prophylaxis against human malaria. However, primaquine is too toxic and can not be used