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为了解除人畜常被杀虫剂有机磷酸酯所致的中毒症状,文献曾报道一系列乙酰胆碱酯酶复能剂的研究和机理探讨,其中用于临床的有吡啶2-甲醛肟碘或氯甲烷盐等.ciba公司和schnekenburger等曾先后合成若干肟醚类和吡啶N-氧化物甲醛肟酯类季铵盐.作者设想合成若干吡啶甲醛肟酯季铵盐,但在肟酯的季铵化过程中,2-位异构体都未得到预期的产物,而是在季铵化的同时,发生β-消除反应,除苯环中有强
In order to relieve the symptoms of poisoning caused by organophosphate pesticides often used by humans and animals, a series of studies on acetylcholinesterase and its mechanism have been reported in the literature. Among them, there are pyridine 2-formaldehyde oxime iodine or methyl chloride Etc. Ciba and schnekenburger et al have synthesized a number of oxime ethers and pyridine N-oxide formaldehyde oxime ester quaternary ammonium salt. The authors envisaged the synthesis of a number of picolinaldehyde oxime ester quaternary ammonium salt, but in the oxime ester quaternization process , 2-position isomers did not get the desired product, but in the quaternary at the same time, β-elimination reaction occurs, in addition to strong benzene ring