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测定４８例癌性胸液和３３例良性胸液中癌胚抗原（ＣＥＡ）、糖链抗原５０（ＣＡ５０）、α－抗胰蛋白酶（α－ＡＴ）、唾液酸（ＳＡ）及铁蛋白（Ｆｒ）含量，评价其鉴别诊断价值。结果：①癌性胸液组ＣＥＡ、ＣＡ５０水平显著高于良性胸液组（Ｐ＜００１），分别以大于１０μｇ／Ｌ和１２ｋＵ／Ｌ为阳性界值，ＣＥＡ和ＣＡ５０对癌性胸液的诊断敏感性分别为７７１％和６６７％，特异性均为９７％。②ＣＥＡ、ＣＡ５０在癌性胸液中分布无显著相关性（ρ＜０４，Ｐ＞００５），可以互补。两指标联合测定建立判断函数，对癌性胸液的诊断敏感性、特异性和准确率分别为７５％、１００％和８４２％。③α－ＡＴ、ＳＡ、Ｆｒ在癌性胸液和良性胸液中含量无显著性差异（Ｐ＞００５），无鉴别诊断价值
The carcinoembryonic antigen (CEA), carbohydrate antigen 50 (CA50), α-antitrypsin (α-AT), sialic acid (SA) and ferritin (Fr) were determined in 48 cases of malignant pleural effusion and 33 benign pleural fluids. ) Content, evaluate its differential diagnostic value. Results: 1 The levels of CEA and CA50 in cancerous effusion group were significantly higher than those in benign pleural fluid group (P<001), with positive boundary values greater than 10 μg/L and 12 kU/L, respectively. CEA and CA50 were positive for cancerous pleural fluid. The diagnostic sensitivities were 77.1% and 66.7%, respectively, and the specificity was 97%. 2There was no significant correlation between the distribution of CEA and CA50 in cancerous pleural fluid (ρ<04, P>005) and they could be complementary. The combined determination of the two indexes established a judgment function. The diagnostic sensitivity, specificity, and accuracy of cancer pleural fluid were 75%, 100%, and 84. 2%, respectively. 3α-AT, SA, Fr had no significant difference in cancerous pleural fluid and benign pleural fluid (P>005), and no differential diagnostic value.