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活性氧族是一类氧衍生的代谢物,被广泛地认为是多种生理过程以及病理状态下关键的调节剂,在血管系统中主要由还原型辅酶Ⅱ氧化酶生成。慢性创口的愈合涉及2种不同形式的血管新生:血管发生(骨髓来源分化而成的循环内皮祖细胞形成)和血管生成(已存在血管局部内皮细胞的芽生而形成)。活性氧族通过对血管新生过程中所涉及的内皮祖细胞、内皮细胞和血管平滑肌细胞功能的调节,影响创口愈合。
The reactive oxygen species, a class of oxygen-derived metabolites, are widely recognized as key regulators of a variety of physiological processes and pathologies and are primarily produced by the reduced coenzyme II oxidase in the vascular system. The healing of chronic wounds involves two different forms of angiogenesis: angiogenesis (formation of circulating endothelial progenitor cells derived from bone marrow differentiation) and angiogenesis (the formation of pre-existing vascular endothelial cells). Reactive oxygen species affect wound healing by modulating the function of endothelial progenitor cells, endothelial cells and vascular smooth muscle cells involved in angiogenesis.