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研究观察纳洛酮和狄普诺芬(M5050)对大肠杆菌内毒素休克狗血液动力学指标的影响。静脉注射纳洛酮(2mg/kg)和侧脑室注射M5050(40μg/狗),明显增加内毒素休克狗左心室内压、左心室内压最大上升速度、心脏每搏量及心输出量,平均动脉血压也显著回升。静脉注射M5050(2mg/kg)对内毒素休克狗血液动力学指标无明显作用。结果表明M5050改善内毒素休克狗的血液动力学的作用部位似在中枢神经系统,提示内毒素休克时中枢的内源性阿片样物质在休克发病学中的作用可能更为重要。
To study the effects of naloxone and dibenzofen (M5050) on hemodynamics of E. coli endotoxin-induced beagle dogs. Intravenous injection of naloxone (2mg / kg) and intracerebroventricular injection of M5050 (40μg / dog), significantly increased endotoxin shock left ventricular pressure, maximum rate of left ventricular pressure rise, cardiac stroke volume and cardiac output, the average Arterial blood pressure also significantly increased. Intravenous injection of M5050 (2 mg / kg) had no effect on hemodynamic parameters in endotoxic shock dogs. The results suggest that M5050 improves the hemodynamic role of dogs in endotoxic shock in the central nervous system, suggesting that central endogenous opioids during endotoxic shock may be more important in shock pathogenesis.