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目的研究血浆N端B型钠尿肽前体(NT-proBNP)水平对急诊患者呼吸困难鉴别诊断意义。方法对我院急诊科呼吸困难患者,检测血浆NT-proBNP含量,并进行超声心动图检查,比较心源性和肺源性呼吸困难患者血浆NT-proBNP水平的差异。结果心源性呼吸困难组和肺源性呼吸困难组血浆NT-proBNP分别为(471.40±190.99)pg/mL和(84.77±24.17)pg/ml(P<0.01);心源性呼吸困难组血浆NT-proBNP与左室射血分数呈负相关(r=-0.82,P<0.01)。结论血浆NT-proBNP对心源性呼吸困难和肺源性呼吸困难的鉴别诊断有重要意义。
Objective To investigate the significance of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) level in the differential diagnosis of dyspnea in emergency patients. Methods The patients with dyspnea in emergency department of our hospital were tested for plasma NT-proBNP levels and echocardiography. The differences of plasma NT-proBNP levels between patients with cardiogenic and pulmonary dyspnea patients were compared. Results The plasma levels of NT-proBNP were (471.40 ± 190.99) pg / mL and (84.77 ± 24.17) pg / ml, respectively, in cardiorespiratory dysfunction group and pulmonary dyspnea group (P <0.01) NT-proBNP was negatively correlated with left ventricular ejection fraction (r = -0.82, P <0.01). Conclusion Plasma NT-proBNP is of great significance in the differential diagnosis of cardiogenic dyspnea and pulmonary-derived dyspnea.