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以环十二酮为原料合成了cis-2-苯磺酰基-12-苄基环十二酮、2-苯磺酰基-12-溴代环十二酮和2,12-二苄基环十二酮,它们的结构通过1H NMR,13C NMR和元素分析表征.化合物4的晶体结构参数:C25H32O3S,Mr=412.57,三斜晶系,空间群P1,a=0.96531(4)nm,b=1.12703(5)nm,c=1.17486(5)nm,α=89.278(2)°,β=75.582(2)°,γ=65.385(2)°,V=1.11938(8)nm3,Dc=1.224 g/cm3,Z=2,F(000)=444,μ(Mo Kα)=0.167 mm-1,S=1.038.化合物6的晶体结构参数:C18H25BrO3S,Mr=401.35,三斜晶系,空间群P1,a=0.77771(16)nm,b=1.0143(2)nm,c=1.2040(2)nm,α=89.46(3)°,β=80.13(3)°,γ=75.27(3)°,V=0.9044(3)nm3,Dc=1.474 g/cm3,Z=2,F(000)=416和μ(Mo Kα)=2.400 mm-1,S=1.042.cis-2-苯磺酰基-12-苄基环十二酮和cis-2-苯磺酰基-12-溴代环十二酮的X射线衍射结果表明,环十二酮母体骨架采取[3333]-2-酮构象,较小的取代基位于角顺位,较大的取代基位于边外向位.
The synthesis of cis-2-benzenesulfonyl-12-benzylcyclododecanone, 2-benzenesulfonyl-12-bromocyclododecanone and 2,12-dibenzylidene cyclamate Dione and their structures were characterized by 1H NMR, 13C NMR and elemental analysis.The crystal structure parameters of compound 4: C25H32O3S, Mr = 412.57, triclinic system, space group P1, a = 0.96531 (4) nm, b = 1.12703 Α = 89.278 (2) °, β = 75.582 (2) °, γ = 65.385 (2) °, V = 1.11938 (8) nm3 and Dc = 1.224 g / cm 3, Z = 2, F (000) = 444, μ (Mo Kα) = 0.167 mm -1 and S = 1.038. The crystal structure parameters of compound 6 are: C18H25BrO3S, Mr = 401.35, triclinic system, space group P1, α = 89.46 (3) °, β = 80.13 (3) °, γ = 75.27 (3) °, a = 0.77771 (16) nm and b = 1.0143 0.9044 (3) nm3, Dc = 1.474 g / cm3, Z = 2, F (000) = 416 and μ (Mo Kα) = 2.400 mm-1, S = 1.042.cis-2-benzenesulfonyl- The results of X-ray diffraction of the cyclosododecanone and cis-2-benzenesulfonyl-12-bromocyclododecanone show that the cyclododecanone parent skeleton adopts the conformation of [3333] -2-one, the smaller substituent Located in the cis position, the larger substituent is located in the lateral position.