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目的探讨低剂量甲巯咪唑(他巴唑)治疗甲状腺功能亢进症(甲亢)的临床疗效。方法选取2014年8月—2015年2月郫县中医医院收治的甲亢患者90例,均符合甲亢诊断标准。按治疗方式不同分为对照组与观察组,各45例。对照组予以他巴唑(30mg/次口服)治疗,观察组予以他巴唑(10mg/次口服)治疗。比较两组患者临床疗效、治疗前后甲状腺激素水平及不良反应发生情况。结果观察组总有效率为95.56%,高于对照组的86.67%,差异有统计学意义(P<0.05)。治疗前两组甲状腺激素水平比较,差异无统计学意义(P>0.05);治疗后观察组游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平低于对照组,差异有统计学意义(P<0.05);治疗后两组血清促甲状腺素(TSH)水平比较,差异无统计学意义(P>0.05)。观察组不良反应发生率为6.66%,低于对照组的17.78%,差异有统计学意义(P<0.05)。结论低剂量他巴唑治疗甲亢的临床疗效确切,可有效减少甲状腺激素分泌,且不良反应少。
Objective To investigate the clinical efficacy of low dose methimazole (methimazole) in the treatment of hyperthyroidism (hyperthyroidism). Methods 90 patients with hyperthyroidism who were treated in Juxian Hospital of Traditional Chinese Medicine from August 2014 to February 2015 were selected, all of which met the diagnostic criteria of hyperthyroidism. According to different treatment methods were divided into control group and observation group, 45 cases each. The control group was treated with methimazole (30mg / orally), and the observation group was treated with methimazole (10mg / orally). The clinical efficacy, thyroid hormone levels and adverse reactions before and after treatment were compared between the two groups. Results The total effective rate in the observation group was 95.56%, which was higher than that in the control group (86.67%), the difference was statistically significant (P <0.05). There was no significant difference in thyroid hormone levels between the two groups before treatment (P> 0.05). After treatment, the free triiodothyronine (FT3) and free thyroxine (FT4) in the observation group were lower than those in the control group (P <0.05). There was no significant difference in serum thyrotropin (TSH) levels between the two groups after treatment (P> 0.05). The incidence of adverse reactions in the observation group was 6.66%, lower than 17.78% in the control group, the difference was statistically significant (P <0.05). Conclusions Low dose methbazole treatment of hyperthyroidism clinical efficacy is exact, can effectively reduce thyroid hormone secretion, and adverse reactions.