论文部分内容阅读
目的 C反应蛋白对2型糖尿病肾脏损害发生的预测价值。方法选择2型糖尿病和早期糖尿病肾病患者为研究对象,进行CRP、肾脏损伤等相关因素检测,以炎症状态分组后进行生存分析,评估炎症状态对糖尿病肾病预后的影响。结果 150例患者CRP平均水平为(4.27±1.19)mg/L,早期糖尿病肾病组CRP平均水平显著高于2型糖尿病组(5.89±1.33vs3.95±1.12t=4.627P<0.001),两组患者血压、血清肌酐及血清Cys-C无统计学差异(P>0.05)。以蛋白尿和eGFR下降为终点事件,随访结束时,CRP升高组患者显性白蛋白尿和eGFR下降终点事件发生率显著高于CRP正常组,为31.11%VS16.00%,χ2=4.233P=0.040。结论炎症状态是影响早期糖尿病肾脏病预后一个危险因素。
Predictive value of C-reactive protein in the pathogenesis of type 2 diabetic nephropathy. Methods Patients with type 2 diabetes mellitus and early diabetic nephropathy were enrolled in this study. CRP and renal injury were detected. Survival analysis was performed after grouping with inflammatory state to evaluate the effect of inflammatory state on the prognosis of diabetic nephropathy. Results The average level of CRP in 150 patients was (4.27 ± 1.19) mg / L, the average level of CRP in early diabetic nephropathy group was significantly higher than that in type 2 diabetic patients (5.89 ± 1.33 vs 3.95 ± 1.12t = 4.627 P <0.001) Blood pressure, serum creatinine and serum Cys-C had no statistical difference (P> 0.05). At the end of follow-up, patients with elevated CRP had significantly lower rates of overt and eGFR endpoints than those with normal CRP, with 31.11% VS 16.00% and χ2 = 4.233 P = 0.040. Conclusion Inflammatory state is a risk factor affecting the prognosis of early diabetic nephropathy.