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为了研究中药坚骨液对大鼠实验性骨质疏松的治疗作用，应用切除卵巢造成的大鼠骨质疏松模型，以雌二醇和自来水为对照，观察了坚骨液对造模动物骨代谢的影响。结果显示，坚骨液和雌二醇组动物的骨密度、血钙水平均明显高于自来水对照组（Ｐ＜０．０５），而２４小时尿钙、尿羧脯氨酸的含量及血浆酸性磷酸酶活性显著降低（Ｐ＜０．０５）。说明坚骨液能改善造模动物的体内钙负平衡状态和抑制骨吸收，对雌激素缺失引起的骨质疏松有很好的防治作用。
In order to study the therapeutic effect of Chinese herbal medicine Jianguye on experimental osteoporosis in rats, the model of rat osteoporosis caused by ovariectomy was used to observe the bone metabolism of Jianguye on model animals in comparison with estradiol and tap water. influences. The results showed that the bone density and serum calcium levels in the Jianguye and estradiol group were significantly higher than those in the tap water control group (P<0.05), while the 24-hour urinary calcium and urinary carboxyproline contents and plasma acidity were significantly higher. Phosphatase activity was significantly reduced (P<0.05). It shows that Jianguye can improve the negative balance of calcium in model animals and inhibit bone resorption. It has a good preventive effect on osteoporosis caused by estrogen deficiency.