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目的 探讨内皮抑素和血管内皮生长因子 (VEGF )在喉癌和声带息肉中的表达及意义。方法 用免疫组化法检测 4 8例喉癌和 2 0例声带息肉患者手术切除标本内皮抑素和VEGF的表达。结果 ①喉癌组织中内皮抑素的高表达率和VEGF的阳性表达率分别为 6 2 .5 %和 6 8.8%。内皮抑素和VEGF呈正相关 (P =0 .0 0 5 ) ,在有颈淋巴结转移的喉癌标本中内皮抑素高表达率和VEGF阳性表达率明显高于非转移组 (P =0 .0 12 ) ;②声带息肉中VEGF无表达 ,内皮抑素表达低于喉癌组织 ,二者无相关性。结论 内皮抑素和VEGF的表达可作为预测喉癌患者的预后因素
Objective To investigate the expression of endostatin and vascular endothelial growth factor (VEGF) in laryngeal carcinoma and vocal cord polyp. Methods Immunohistochemistry was used to detect the expression of endostatin and VEGF in surgical specimens of 48 cases of laryngeal carcinoma and 20 cases of vocal cord polyp. Results ① The high expression of endostatin and VEGF in laryngeal carcinoma tissues were 62.5% and 68.8%, respectively. There was a positive correlation between endostatin and VEGF (P = 0.05). The high expression rate of endostatin and VEGF in laryngeal carcinoma with cervical lymph node metastasis was significantly higher than that in non-metastasis group (P = 0. 0 0) 12); vocal cord polyps VEGF expression, endostatin expression is lower than laryngeal cancer, both no correlation. Conclusion The expression of endostatin and VEGF can be used as predictors of prognosis in patients with laryngeal cancer