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按ＷＨＯ标准选择１７１例被动物Ⅲ度咬伤者联合使用法国产ＰＶＲＶ和ＥＲＩＧ进行免疫，观察其免疫效果、全身及局部反应，评价其有效性和安全性。结果表明，全身反应发生率为７．６０％，ＰＶＲＶ和ＥＲＩＧ局部反应发生率分别为１．３０％和１０．５３％。应用ＲＦＦＩＴ动态检测５１例患者，第０、７、１４和２８天的阳性率分别为０％、４１．１８％、１００％和１００％，ＧＭＴ分别为０．０３、０．３８、１１８．８３和９６．２９ＩＵ。联合使用ＰＶＲＶ和ＥＲＩＧ进行免疫，异常反应少而轻，安全性好；中和抗体免后第１４天即达到高峰
According to the WHO standard, 171 cases of rabbits with grade Ⅲ bite were selected and immunized with PVRV and ERIG. The immunological effects, systemic and local reactions were observed and their efficacy and safety were evaluated. The results showed that the incidence of systemic reactions was 7.60%, PVRV and ERIG local reactions were 1.30% and 10.53% respectively. 51 cases were detected by RFFIT. The positive rates of 0, 7, 14 and 28 days were 0%, 41.18%, 100% and 100%, respectively, and the GMTs were 0.03, 0.38 and 118.83 And 96.29 IU. The combined use of PVRV and ERIG immunization, less abnormal reaction and light, good safety; neutralizing antibody 14 days after the peak was reached