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激素疗法是肿瘤的辅助疗法之一,实验研究证明性激素对喉有影响,喉癌发展的特点同雄激素含量相对增高有关,用人造雌酚疗法可直接作用于肿瘤并刺激机体的防御反应。雌激素能刺激吞噬细胞活动,提高血清γ球蛋白浓度。刺激网状内皮系统防止肿瘤扩散,是雌激素治疗乳腺癌的机制之一。作者观察喉癌40例,都是男性,年龄40～70岁。组织学检查确诊,都是扁平细胞癌,其中角化性癌24例,非角化性10例,低度分化6例。由于大多数病例拒绝手术,施行人造雌酚
Hormone therapy is one of the adjunctive therapies for tumors. Experimental studies have shown that sex hormones affect the larynx. The characteristics of laryngeal cancer development are related to the relatively high levels of androgens. The use of artificial oestrogen therapy can directly act on the tumor and stimulate the body’s defense response. Estrogen stimulates phagocyte activity and increases serum gamma globulin concentrations. Stimulating the reticuloendothelial system to prevent tumor proliferation is one of the mechanisms of estrogen therapy for breast cancer. The authors observed 40 cases of laryngeal cancer, all male, aged 40 to 70 years old. Histological examination confirmed the diagnosis of squamous cell carcinoma, including 24 cases of keratinizing cancer, 10 cases of non-keratinizing, and 6 cases of low-grade differentiation. As the majority of cases refused to undergo surgery, an artificial estrone was administered