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虽然目前对肾移植后促进动脉粥样硬化的原因尚不清楚,但有许多文献报道肾移植后动脉粥样硬化的发病率不仅比一般人高几倍,而且也是导致这类患者死亡的一个重要因素。本文作者调查了1977年1月至1986年12月10年间接受464次肾移植的403名患者。平均随访时间为46.1±36.2月,平均年龄40.6±12.9岁,91％被移植者为白人、55为男性、21％肾衰是由于糖尿病所致,96％被移植的肾脏来自尸体。幸存时间到1987年5月底止为46.1±36.2(0—135)月。结果在肾移植后的随访中动脉粥样硬化的发病率为15.8％,当注意到移植前心血管疾病时经统计学多元分析发现若干危险因素如年龄、性别、糖尿病、吸烟、高血压和血清胆固醇均与移植后的心血管疾病有着密切的联系,另外急性排斥反应同样也与心血管病有关。根据上述调查,作者指出在肾移植患者中减少已知的危险因素(如高血压、高胆固醇和吸烟)及
Although the reasons for atherosclerosis promotion after renal transplantation are not yet clear, there are many reports that the incidence of atherosclerosis after kidney transplantation is not only several times higher than the average person, but also an important factor leading to the death of such patients . The authors investigated 403 patients who underwent 464 kidney transplants between January 1977 and December 1986. The average follow-up time was 46.1 ± 36.2 months, with an average age of 40.6 ± 12.9 years. 91% of the transplanted patients were white, 55 were male, 21% of renal failure was due to diabetes, and 96% of the transplanted kidneys were from the body. The survival time was 46.1 ± 36.2 (0-135) months until the end of May 1987. Results The incidence of atherosclerosis at follow-up after renal transplantation was 15.8%. A statistical multivariate analysis of several risk factors such as age, gender, diabetes, smoking, hypertension, and serum was found when pre-transplant cardiovascular disease was noted Cholesterol and cardiovascular disease after transplantation are closely linked, in addition to acute rejection is also associated with cardiovascular disease. Based on the above investigation, the authors point out that known risk factors (such as hypertension, hypercholesterolemia and smoking) and renal impairment in renal transplant recipients