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为研究镉对骨组织的直接作用，本文利用骨形态发生蛋白（BMP）建立诱导性异位成骨模型，研究了镉对软骨和骨形成的影响．采用35S、40Ca掺入率及碱性磷酸酶（ALP）和酸性磷酸酶（ACP）活性4项指标反映软骨和骨的形成情况．结果表明，镉对软骨形成过程中的35S掺入率无明显影响，但能使骨形成过程中40Ca掺入率下降，镉能抑制ALP活性，但对ACP活性无明显影晌．由此可见，镉对软骨形成无明显影响，但对软骨内成骨细胞却有明显的抑制作用，镉能抑制成骨细胞的功能和钙盐沉积．
In order to study the direct effect of cadmium on bone tissue, an induced ectopic osteogenesis model was established using bone morphogenetic protein (BMP) to study the effect of cadmium on cartilage and bone formation. The incorporation rate of 35S and 40Ca and the activity of alkaline phosphatase (ALP) and acid phosphatase (ACP) were used to reflect the formation of cartilage and bone. The results showed that cadmium had no effect on the incorporation rate of 35S during cartilage formation but decreased the incorporation rate of 40Ca during bone formation. Cadmium inhibited ALP activity but had no effect on ACP activity. Thus, cadmium has no significant effect on the formation of cartilage, but it has a significant inhibitory effect on intracellular cartilage osteoblasts. Cadmium can inhibit osteoblast function and calcium deposition.