五、免疫学对丝虫感染的免疫反应的了解远远落后于许多其他重要的医学寄生虫。由于缺乏合适的动物模型,免疫学家未能研究丝虫感染。丝虫免疫学要取得真正的进展,必须建立纯系鼠的模型。虽然在自然界鼠类感染了种种丝虫,但很少在纯系鼠类中建立模型。这些鼠类丝虫的缺点是不感染淋巴管。然而,吴策属和布鲁属丝虫在其脊椎动物宿主体内的生活史中,都有淋巴管外的感染性幼虫和微 V. Immunology Understanding of the immune response to filarial infections lags far behind many other important medical parasites. In the absence of a suitable animal model, immunologists have failed to study filarial infections. To make real progress in Filarias immunology, it is necessary to establish a model of purebred rats. Although rodents are infected with a variety of filariasis in nature, it is seldom established in pure-line mice. The disadvantage of these rodent filariasis is that it does not infect lymphatic vessels. However, both the genus Umbellius and the genus Brucella in the life history of their vertebrate hosts have infectious lymphatic larvae and micro