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目的:探讨端粒酶催化亚单位(hTERT)在大肠癌患者中的表达情况及与及临床病理类型、淋巴结转移和复发之间的关系.方法:免疫组化法测定大肠癌组织(n=45)、腺瘤组织(n=16)及正常大肠黏膜(n=10)hTERT表达情况,并将hTERT表达情况与大肠癌临床病理类型、淋巴结转移和肿瘤复发之间的关系进行总结.结果:大肠癌患者癌组织中的hTERT阳性率为77.8%,显著高于腺瘤组(2/16)和正常大肠黏膜组(0/10),有显著性差异(P<0.05).hTERT表达强度与淋巴结转移呈高度相关性(r=5.2,P<0.05).大肠癌复发转移平均时间阳性组为34±5mo,阴性组为20±6mo,差异有显著性(P<0.05).结论:hTERT在大肠癌组织中有高表达,hTERT免疫组化检测结果可以作为大肠癌早期诊断和淋巴结转移的一个重要参考指标.
Objective: To investigate the expression of telomerase catalytic subunit (hTERT) in patients with colorectal cancer and its relationship with clinicopathological type, lymph node metastasis and recurrence.Methods Immunohistochemical method was used to detect the expression of hTERT in colorectal cancer tissues (n = 45 ), Adenoma (n = 16) and normal colorectal mucosa (n = 10), and the relationship between hTERT expression and clinicopathological types, lymph node metastasis and recurrence of colorectal cancer were summarized.Results: The positive rate of hTERT in cancer tissue was 77.8%, which was significantly higher than that in adenoma group (2/16) and normal colorectal mucosa group (0/10) (P <0.05) .The expression of hTERT was significantly correlated with lymph node (R = 5.2, P <0.05) .The average time of recurrence and metastasis of colorectal cancer was 34 ± 5mo, the negative group was 20 ± 6mo, the difference was significant (P <0.05) .Conclusion: hTERT in the large intestine High expression of cancer tissue, hTERT immunohistochemical test results can be used as early diagnosis of colorectal cancer and lymph node metastasis is an important reference index.