全身性感染是导致ＩＣＵ患者急性肾功能衰竭(ＡＲＦ)和死亡的主要原因[1,2],其发生机制非常复杂,可以看成是局部或全身产生的炎症介质,进入血循环后所导致的严重全身性炎症反应,人们研究了多种针对特异性炎症介质的治疗方法,但在大样本的临床研究中未能证实可降低患者的死亡率[ Systemic infection is the leading cause of acute renal failure (ARF) and death in ICU patients [1,2], and its mechanism is very complex and can be thought of as a local or systemic inflammatory mediator, resulting in serious consequences of entering the bloodstream Systemic inflammatory response, a variety of treatments for specific inflammatory mediators have been investigated, but failure to demonstrate reduced mortality in large sample clinical studies [