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建立人乳腺癌移植瘤裸鼠模型,随机分为生理盐水(NS)组、顺铂(DDP)组、低剂量三氧化二砷(As2O3)组和高剂量As2O3组。用药4周后,观察裸鼠一般状况的变化、用药前后肿瘤生长情况、裸鼠体质量变化及免疫组化检测其可能的机制。发现As2O3组肿瘤大小和瘤重均较NS组明显缩小,给药后裸鼠未见明显不良反应,且As2O3能诱导癌细胞凋亡,调控相关基因表达。认为As2O3对裸鼠乳腺癌移植瘤有显著的抗肿瘤作用,诱导肿瘤细胞凋亡可能是As2O3的抗肿瘤机制之一。
A nude mouse model of human breast cancer xenografts was established and randomly divided into normal saline (NS) group, cisplatin (DDP) group, low dose arsenic trioxide (As2O3) group and high dose As2O3 group. After 4 weeks of treatment, changes in the general condition of the nude mice, tumor growth before and after administration, changes in body weight of nude mice, and possible mechanisms of immunohistochemistry were observed. The tumor size and tumor weight in the As2O3 group were significantly smaller than those in the NS group. No adverse reactions were observed in the nude mice after administration, and As2O3 could induce apoptosis of cancer cells and regulate the expression of related genes. It is considered that As2O3 has a significant anti-tumor effect on breast cancer xenografts in nude mice, and induction of tumor cell apoptosis may be one of the anti-tumor mechanisms of As2O3.