Over the past ten years,the enthusiasm to harness small RNA molecules,mainly small interfering RNAs(siRNAs) and microRNA mimics,into therapeutic weapons has never been quenched.However,a major obstacle hindering the clinical application of these small molecules is how to efficiently and precisely deliver siRNAs in vivo into target cells to silence target genes.An international collaborative study led by Song Erwei from the Memorial Hospital of Sun-YatSen University and Wang Jun from Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences of University of Science and Tech- Over the past ten years, the enthusiasm to harness small RNA molecules, mainly small interfering RNAs (siRNAs) and microRNA mimics, into therapeutic weapons has never been quenched. Host, a major obstacle hindering the clinical application of these small molecules is how efficiently and ‧ deliver siRNAs in vivo into target cells to silence target genes. An international collaborative study led by Song Erwei from the Memorial Hospital of Sun-YatSen University and Wang Jun from Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences of University of Science and Tech-