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目的通过检测结核病患者血浆及胸水中白细胞介素6(IL-6)的浓度变化情况,探讨IL-6与结核菌感染的临床转归、疾病严重程度的关系。方法用ELISA法检测30例健康体检者、30例潜伏感染者、30例活动性肺结核患者、20例结核性脑膜炎患者及20例结核性胸膜炎患者血浆和胸水中的IL-6的浓度。结果肺结核患者血浆中IL-6水平明显高于健康对照组及结核潜伏感染者(P<0.01,P<0.01);结核性胸膜炎患者血浆中IL-6水平明显高于肺结核患者(P=0.0029);结核性胸膜炎患者胸水中的IL-6显著高于相应血浆中IL-6水平(P<0.0001)。结论 IL-6与结核菌感染的临床转归、结核病严重程度相关,是局部病灶炎症反应的重要作用因子。
Objective To explore the relationship between IL-6 and the clinical outcome of tuberculosis infection and the severity of the disease by detecting the concentration of interleukin-6 (IL-6) in plasma and pleural effusion of patients with tuberculosis. Methods The concentrations of IL-6 in plasma and pleural effusion of 30 healthy subjects, 30 latent patients, 30 active pulmonary tuberculosis patients, 20 patients with tuberculous meningitis and 20 patients with tuberculous pleurisy were detected by ELISA. Results The plasma level of IL-6 in patients with tuberculosis was significantly higher than that in healthy controls and tuberculosis latent patients (P <0.01, P <0.01). The plasma level of IL-6 in patients with tuberculous pleurisy was significantly higher than that in patients with tuberculosis (P = 0.0029) ; Tuberculous pleurisy pleural effusion IL-6 was significantly higher than the corresponding plasma IL-6 levels (P <0.0001). Conclusion IL-6 is associated with the clinical outcome of tuberculosis infection and the severity of tuberculosis, which is an important factor of inflammation in local lesion.