过去30年来,与大量服用止痛剂有关的慢性间质性肾炎日益增多,世界各地皆有报道.直到10年前,人们还认为止痛剂伴随性肾病(AAN)作为慢性肾病的病因,在美国不占重要地位,但近来的观察强烈提示并非如此.实际上,在美国,一切慢性肾衰竭中至少6%、间质性肾病中至少20%是AAN引起的. Over the past 30 years, chronic interstitial nephritis associated with heavy use of analgesics has been reported in many parts of the world, and it was not until 10 years ago that analgesic-associated nephropathy (AAN) was also considered as the cause of chronic kidney disease But recent observations strongly suggest that this is not the case.In fact, in the United States, at least 6% of all chronic renal failure and at least 20% of interstitial nephropathy are caused by AAN.