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为了寻找新的含苯并噻唑稠杂环农药先导化合物,利用取代2-肼基苯并噻唑与取代苯甲酸在三氯氧磷中回流反应,合成了18个新型取代3-芳基-1,2,4-三唑并[3,4-b]苯并噻唑化合物,并利用1H NMR,EI-MS及元素分析对其结构进行了表征.初步生物活性试验结果表明,在50 mg/L浓度下,部分目标化合物对立枯丝核菌(Rhizoctonia solani)、西瓜壳二孢菌(Ascochyta citrullina)、香蕉枯萎病菌(Fusarium oxysporum f.sp.cubense)、烟草炭疽病菌(Colletotrichum nicotianae)具有中等杀菌活性.然而,部分化合物对灰葡萄孢菌(Botrytis cinerea)反而起到一定促进生长作用.
In order to find a new precursor compound of benzothiazole fused heterocyclic pesticides, 18 novel substituted 3-aryl-1 were synthesized by refluxing substituted 2-hydrazinobenzothiazole with substituted benzoic acid in phosphorus oxychloride, The structure of 2,4-triazolo [3,4-b] benzothiazole was characterized by 1H NMR, EI-MS and elemental analysis. The results of preliminary bioassay showed that under the concentration of 50 mg / L , Some of the target compounds have moderate bactericidal activity against Rhizoctonia solani, Ascochyta citrullina, Fusarium oxysporum f.sp.cubense and Colletotrichum nicotianae. However, some of the compounds on the contrary to Botrytis cinerea play a role in promoting growth.