1964年Skipper等提出了杀细胞的假说,即大部分肿瘤化疗药物的作用原理是通过干扰细胞的增殖周期直接杀伤细胞。而Hiatt等又提出了另外一些可能的作用原理,他认为,现今所用药物的主要问题不在于它们不能起治愈作用,而在于未能探求出它们对于肿瘤细胞的特殊代谢途径。 Rose认为肿瘤化疗药物能产生暂时的免疫活化作用或逆转机体对肿瘤的免疫耐受性。并假设药物治疗的失败可归咎于免疫活化作用的丧失或总体免疫受抑制,在某些情况下,这些可由药物所导致。本文根据最近 In 1964, Skipper et al. proposed the hypothesis of killing cells that the principle of action of most cancer chemotherapy drugs is to directly kill cells by interfering with the cell proliferation cycle. Hiatt et al. proposed other possible principles of action. He believes that the main problem with today’s drugs is not that they do not have a curative effect, but that they cannot find out their specific metabolic pathways for tumor cells. Rose believes that cancer chemotherapeutics can produce temporary immune activation or reverse the body’s immune tolerance to tumors. And it is hypothesized that the failure of drug treatment can be attributed to the loss of immune activation or the suppression of overall immunity, and in some cases these can be caused by drugs. This article is based on recent