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目的 了解血浆内皮素(ET)与肺炎的发生、发展及疾病的关系。方法 放免法检测73 例肺炎患儿ET。结果 重症肺炎组(112.61±26.74ng/L)较普通肺炎组(66.71±20.86ng/L)明显升高(P< 0.001);危重度评分在70～90 分组(131.18±27.33ng/L)明显高于评分大于90分组(73.95±24.05ng/L)(P< 0.001)。结论 ET参与重症肺炎的发生、发展,与疾病轻重呈相关性,探索新的有效ET拮抗剂或单克隆抗体能为临床诊断治疗和判断预后提供新的途径
Objective To understand the relationship between plasma endothelin (ET) and the occurrence, development and disease of pneumonia. Methods Radiofrequency ablation was used to detect ET in 73 children with pneumonia. Results The severity of severe pneumonia (112.61 ± 26.74ng / L) was significantly higher than that of the common pneumonia group (66.71 ± 20.86ng / L) (P <0.001). The severity of severe pneumonia was significantly higher in the 70-90 group (131.18 ± 27.33ng / L) Higher than the score greater than 90 group (73.95 ± 24.05ng / L) (P <0.001). Conclusions ET is involved in the occurrence and development of severe pneumonia and is correlated with severity of disease. To explore new and effective ET antagonist or monoclonal antibody may provide a new approach for clinical diagnosis and treatment and prognosis