论文部分内容阅读
在变异性心绞痛病人,不论其冠状动脉正常或有固定阻塞性病变,发生心绞痛的原因是冠状动脉痉挛。因此,要找到治疗变异性心绞痛的有效方法,必须弄清冠状动脉痉挛的病理生理机理。本文旨在综合有关自主神经系统在冠状动脉痉挛中的作用,以提出一个统一的假说。方法:8例变异性心绞痛病人,均作左心导管心室造影和冠状动脉造影,5例并通过冠状窦血流量及平均动脉压计算其冠状血管阻力。检查时患者均处于胸痛发作(2例为自发性,6例用静脉注射麦角新碱诱发),持续监测血压和12导联心电图。然后,静脉给予α-肾上腺素能阻滞剂——酚妥拉明,
In patients with variant angina, regardless of their normal coronary artery or a fixed obstructive disease, angina pectoris is caused by coronary artery spasm. Therefore, to find an effective way to treat variant angina, we must understand the pathophysiology of coronary artery spasm. This article aims to synthesize the role of the autonomic nervous system in coronary artery spasticity to propose a unified hypothesis. Methods: Eight patients with variant angina were treated with left ventricular catheterization and coronary angiography. Five patients were enrolled in this study. Coronary vascular resistance was calculated by coronary sinus blood flow and mean arterial pressure. All patients underwent chest pain at the time of examination (spontaneous in 2 and induced by intravenous ergometrine in 6) with continuous monitoring of blood pressure and 12-lead electrocardiogram. Then, intravenous alpha-adrenergic blockers - phentolamine,