自1979年首次报道恶性疟原虫对氯喹耐药后,丹麦对进入东非国家的旅行者将每周口服氯喹300mg(基质)改为600mg(基质)以预防疟疾。但4年的观察结果表明,恶性疟疾的病例数不断上升。后来改为氯喹与周效磺胺-乙胺嘧啶合用,尽管疟疾病例数下降一半以上,但用周效磺胺-乙胺嘧啶时有严重的副作用产生。因此,作者研究氯喹与氯胍联用的预防效果,并与原来的预防方法进行比较。 Since the first report of Plasmodium falciparum resistance to chloroquine in 1979, Danish travelers to East African countries changed weekly oral chloroquine 300 mg (matrix) to 600 mg (matrix) to prevent malaria. However, the 4-year observation shows that the number of cases of falciparum malaria is on the rise. Chloroquine was later replaced by psoralel-pyrimethamine, although serious side effects were produced with pesosulfan-pyrimethamine despite a more than half reduction in the number of malaria cases. Therefore, the authors studied the prophylactic effect of chloroquine in combination with proguanil and compared it with the original prophylaxis.