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目的:分析高剂量率192Ir后装近距离放疗在中晚期直肠癌治疗中的价值。方法:38例中晚期直肠癌,综合组高剂量率192Ir后装近距离放疗结合外照射放疗20例,对照组单纯外照射18例。高剂量率192Ir后装近距离放疗根据肿瘤形态采用组织间插植术和腔内放疗,2周4次完成,总剂量24Gy～28Gy。1周后加外照射。对照组外照射盆腔野总剂量45Gy～50Gy,2次/d。结果:临床证状改善、局部肿瘤消退情况综合组高剂量率192Ir后装近距离放疗2周疗效与对照组外照射40Gy无明显差异。综合组较单纯外照组提高了1a、3a生存率。结论:高剂量率192Ir后装近距离放疗在晚期直肠癌治疗中有较好的疗较。提高生存率需结合盆腔野外照射放疗。
Objective: To analyze the value of 192Ir high-dose brachytherapy in the treatment of advanced rectal cancer. Methods: Thirty-eight cases of advanced rectal cancer were treated with high-dose 192Ir combined with brachytherapy combined with external beam irradiation in 20 cases. The control group received 18 cases of external irradiation alone. High-dose 192Ir after the installation of brachytherapy according to the tumor morphology using interplanting and intraluminal radiotherapy, 2 weeks 4 times to complete a total dose of 24Gy ~ 28Gy. After 1 week plus external irradiation. In the control group, the total dose of external pelvic irradiation was 45 Gy ~ 50 Gy, twice daily. Results: Clinical symptom improvement and local tumor regression were not significantly different between the two groups in the high dose rate 192Ir after brachytherapy 2 weeks and the control group 40Gy. Compared with the simple radiotherapy group, the comprehensive group increased the survival rate of 1a and 3a. Conclusion: High-dose 192Ir after braided brachytherapy in the treatment of advanced colorectal cancer have a better treatment. To improve the survival rate combined with pelvic radiation therapy.