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切除性腺雄鼠定期接受雌或雄性激素治疗，在１～１８月龄段，经雌二醇治疗的雄鼠平均死亡月龄高于安慰剂组３８％（Ｐ＜０．０１），高于雄激素治疗组６３％（Ｐ＜０．０５）；在１～２１月龄段，经雌二醇和孕酮联合治疗的动物死亡月龄高于雄激素治疗组４６％（Ｐ＜０．０５）。免疫学研究发现，雌二醇可明显提高雄鼠淋巴细胞转化能力（Ｐ＜０．０１）以及腹腔巨噬细胞吞噬能力（Ｐ＜０．００１）。生化研究表明，雌性激素可明显降低雄鼠血中胆固醇含量（Ｐ＜０．０５～０．００５）。结果提示，雌性激素对于延缓衰老具有深远的意义。
In male and female sex hormones, male and female sex hormones were regularly treated with estrogen or androgen therapy. The mean age at death from 1 to 18 months in estradiol-treated male mice was 38% (P <0.01), higher than that of androgen therapy (P <0.05). In the period from 1 to 21 months, the death of animals treated with estradiol and progesterone was 46% higher than that of androgen treatment group (P <0.05). Immunological studies found that estradiol significantly increased lymphocyte transformation ability (P <0.01) and peritoneal macrophage phagocytosis (P <0.001) in males. Biochemical studies have shown that estrogen can significantly reduce the blood cholesterol levels (P <0.05 ~ 0.005). The results suggest that estrogen has far-reaching significance for anti-aging.