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并发肝硬化的慢性活动性丙型肝炎病人常发生肝细胞癌(HCC)。已知IFN对某些这种病人肝功能的改善有效,但对预防HCC的发生是否有作用则不清楚。现报告关于这方面的前瞻性随机对照试验结果。90例临床确诊为并发肝硬化的慢性活动性丙型肝炎病人,随机分为接受IFN-α组(治疗组)或症状组(对照组)。每组各45例病人,年龄、性别比例、输血史或急性肝炎史、肝硬化史、血清白蛋白、ALT和AFP浓度、血
Patients with chronic active hepatitis C complicated with cirrhosis often develop hepatocellular carcinoma (HCC). It is known that IFN is effective for the improvement of liver function in some of these patients, but it is unclear whether it has an effect on preventing the occurrence of HCC. The results of prospective randomized controlled trials in this area are now reported. Ninety patients with chronic active hepatitis C diagnosed with cirrhosis were randomly divided into IFN-α group (treatment group) or symptom group (control group). 45 patients in each group, age, sex ratio, history of blood transfusion or history of acute hepatitis, history of cirrhosis, serum albumin, ALT and AFP concentrations, blood