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树突状细胞(DC)是目前已知体内功能最强的抗原递呈细胞。它通过摄取、加工处理和递呈内外源性抗原以及上调共刺激分子而有效激活初始型T细胞,促进CD+8细胞毒性T细胞及CD+4辅助性T细胞的生成,从而产生特异性抗肿瘤效应[1,2],被称为肿瘤疫苗。DC可从造血干细胞或外周血单核细胞培养获得。近年研究表明,白血病细胞自身可在体外诱导分化为成熟DC,
Dendritic cells (DCs) are currently the most potent antigen-presenting cells in the body. It activates naive T cells by uptake, processing and delivery of endogenous and exogenous antigens as well as upregulation of co-stimulatory molecules, promoting the production of CD8 + T cells and CD + 4 helper T cells, resulting in specific resistance Tumor effects [1,2], known as tumor vaccines. DCs can be obtained from hematopoietic stem cells or from peripheral blood mononuclear cells. Recent studies have shown that leukemia cells themselves can be induced to differentiate into mature DC in vitro,