论文部分内容阅读
目的探讨阿托伐他汀治疗冠心病高脂血症的疗效及机制。方法 123例患者随机分成治疗组和对照组,两组均进行基础治疗,治疗组同期加用阿托伐他汀,20 mg/d,1次/d。对照组同期加用辛伐他汀,20 mg/d,1次/d,疗程均为4周。治疗前后测定两组患者血脂水平。结果给药后,两组血脂水平明显降低,尤其治疗组效果比较明显,与对照组相比有统计学意义(P<0.05)。治疗期间未见明显不良反应。结论阿托伐他汀能够降低血脂水平,是治疗冠心病合并高脂血症安全有效的药物。
Objective To investigate the efficacy and mechanism of atorvastatin in the treatment of coronary heart disease with hyperlipidemia. Methods One hundred and twenty-three patients were randomly divided into treatment group and control group. Both groups were treated with basic therapy. Atorvastatin, 20 mg / d, once daily was used in the treatment group. In the control group, simvastatin was added at the same period, 20 mg / d, once a day for 4 weeks. Blood lipid levels were measured in two groups before and after treatment. Results After administration, serum lipids decreased significantly in both groups, especially in the treatment group, which was statistically significant compared with the control group (P <0.05). No significant adverse reactions during treatment. Conclusions Atorvastatin can reduce blood lipid levels and is a safe and effective drug for the treatment of coronary heart disease complicated with hyperlipidemia.