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体外感染甲型流感病毒可改变人单核细胞及巨噬细胞的某些功能,但淋巴细胞功能无明显变化。如诱导巨噬细胞合成干扰素,减弱巨噬细胞对淋巴细胞致有丝分裂原反应的能力,淋巴细胞感染后对致有丝分裂原反应正常,不产生干扰素。为了探讨流感病毒能否感染人单核细胞及淋巴细胞,作者在体外用流感病毒感染人单个核自细胞(MNLs),并用间接免疫荧光技术和细胞流量计检测和分析细胞表面病毒抗原的表达。
In vitro infection with influenza A virus can change certain functions of human monocytes and macrophages, but no significant changes in lymphocyte function. Such as inducing macrophages to synthesize interferon, attenuating the ability of macrophages to cause mitogenic responses to lymphocytes, normalizing mitogenic responses after lymphocyte infection, and producing no interferons. In order to investigate whether influenza virus can infect human monocytes and lymphocytes, the authors infected human mononuclear cells (MNLs) with influenza virus in vitro and detected and analyzed the expression of virus surface antigens by indirect immunofluorescence and cell flow cytometry.