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目的评价不稳定型心绞痛(UAP)患者调整给药时间的作用。方法对112例不稳定型心绞痛患者随机分为观察组和对照组各56例,两组患者均给予阿司匹林,B受体阻滞剂,硝酸脂类等治疗。观察组采用1次/8 h给药方法:即8Am、4Pm、12MN对照组即按传统的给药即8Am、12N、4Pm。观察两组患者心绞痛发作次数和持续时间及心电图变化。结果观察组患者心绞痛发作次数和持续时间比对照组明显减少,心电图恢复正常或基本正常,临床症状得到缓解和控制,观察组总有效率为92.8%,而对照组总有效率82.1%。两组差异有统计学意义(P<0.05)。结论采用调整给药时间可控制不稳定型心绞痛的发生率,从而提高患者的生存质量。
Objective To evaluate the effect of dosing time in patients with unstable angina pectoris (UAP). Methods A total of 112 patients with unstable angina pectoris were randomly divided into observation group and control group, 56 cases in each group. Both groups were given aspirin, B blockers and nitric acid lipids. Observation group using 1/8 h administration: that is, 8Am, 4Pm, 12MN control group that is according to the traditional administration that is 8Am, 12N, 4Pm. The number and duration of angina attacks and ECG changes in both groups were observed. Results The number and duration of angina pectoris in the observation group were significantly lower than those in the control group. The electrocardiogram returned to normal or almost normal. The clinical symptoms were relieved and controlled. The total effective rate was 92.8% in the observation group and 82.1% in the control group. The difference between the two groups was statistically significant (P <0.05). Conclusion Adjusting the timing of administration can control the incidence of unstable angina pectoris, thereby improving the quality of life of patients.