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雄性Wistar大鼠随机分为对照组(n=9),高甲阴虚组(n=9),低甲阳虚组(n=9)和中药(大黄加蕃泻叶)阳虚组(n=10)。利用高效液相色谱加电化学检测器分析了视前区—下丘脑前部(PO/AH)中单胺类神经递质含量,发现高甲阴虚组中多巴胺(DA)和高香草酸(HVA)含量增加(P<0.01);低甲阳虚组去甲肾上腺素(NE)和中药阳虚组中DA含量低于对照组,差异有显著性(P<0.05)。本文还同步分析了血清中单胺类神经递质含量,结果表明脑组织和血清中单胺类神经递质的含量变化基本上不相关。本文讨论了阴虚阳虚状态下中枢和外周血中单胺美神经递质的变化及其与体温中枢调节功能的关系。
Male Wistar rats were randomly divided into control group (n=9), high-yin-yin deficiency group (n=9), low-yy-yang deficiency group (n=9) and Chinese herbs (rhubarb plus diarrhea) yang deficiency group (n =10). The content of monoamine neurotransmitters in the preoptic area-hypothalamus (PO/AH) was analyzed by high performance liquid chromatography coupled with an electrochemical detector. It was found that dopamine (DA) and homovanillic acid were found in the hyperthyroidism group. The content of HVA) increased (P<0.01). The content of DA in norepinephrine (NE) and the Chinese yang deficiency group was lower than that in the control group. The difference was significant (P<0.05). The monoamine neurotransmitter content in serum was also analyzed simultaneously. The results showed that the content of monoamine neurotransmitters in brain tissue and serum was basically irrelevant. This article discusses the changes of the monoamine neurotransmitters in the central and peripheral blood in the yin-deficiency and yang-deficiency state and its relationship with the regulatory function of the body temperature center.