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目的：检测胰岛素、血糖在正常妊娠和胎儿生长迟缓（ＩＵＧＲ）的母血和脐静脉、脐动脉血中的变化。方法：采用放射免疫法测定胰岛素值，血糖的测定采用葡萄糖氧化酶法。结果：母血中胰岛素值在２８ 周之前无明显变化，在２８ 周时达高峰，之后随孕周的增加而减少，至妊娠末期又达一较高水平，脐静脉、脐动脉血中胰岛素值增高。母血和脐静脉、脐动脉血中的血糖值无明显变化。胎儿生长迟缓母血中的胰岛素和血糖无变化，但是脐静脉、脐动脉血中胰岛素及血糖的变化具有统计学意义（Ｐ＜ ０．０１）。结论：在胎儿生长迟缓的脐静脉、脐动脉血中的胰岛素和血糖是降低的
Objective: To detect the changes of insulin and blood sugar in maternal blood, umbilical vein and umbilical artery of normal pregnancy and fetal growth retardation (IUGR). Methods: The insulin value was determined by radioimmunoassay. Glucose oxidase method was used to determine the blood glucose. Results: The blood insulin level in maternal blood did not change significantly before 28 weeks and peaked at 28 weeks, then decreased with the increase of gestational age. It reached a higher level in the end of pregnancy, and the insulin value in umbilical vein and umbilical artery increased. Blood and umbilical blood in umbilical artery blood glucose values did not change significantly. Fetal growth retardation in maternal blood insulin and blood glucose did not change, but the umbilical vein, umbilical artery blood insulin and blood glucose changes were statistically significant (P <0.01). CONCLUSIONS: Insulin and blood glucose in umbilical arterial blood are reduced in umbilical veins with slow fetal growth