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近年来的流行病学调查和实验室生物学研究结果均表明,血清高密度脂蛋白(HDL)似乎能防止动脉粥样硬化斑块的形成,又能促使斑块的消退。树鼩是一种低级灵长类动物。发现其血清中高密度脂蛋白含量高达血清脂蛋白总量的70％左右。还证实,经高胆固醇—高蛋白饲料较长时间喂养,HDL含量维持不变,LDL也无增加趋势。并发现在动物的胆囊和胆管中有大小不一的胆石颗粒。树鼩有特殊的能力来处理食入的胆固醇,因此认为它是一种理想的模型动物,可用来研究HDL代谢及其在预防动脉粥样斑块形成中的作用。为此,有必要首先分离,提纯三种脂蛋白。
Recent epidemiological and laboratory biologic studies have shown that serum high-density lipoprotein (HDL) appears to prevent the formation of atherosclerotic plaque and promote plaque regression. Tree shrew is a low-grade primate. Found that the serum high-density lipoprotein content of up to about 70% of the total serum lipoprotein. Also confirmed that high cholesterol - high protein feed for a longer time feeding, HDL content remained unchanged, LDL no increase trend. It was also found that there are gallstone particles of varying sizes in the gallbladder and bile duct of animals. Tree shrews have a special ability to handle ingested cholesterol and are therefore considered to be ideal model animals for the study of HDL metabolism and its role in preventing atherosclerotic plaque formation. To this end, it is necessary to first separate and purify the three lipoproteins.