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目的探讨急性胰腺炎并肝损害的临床特征。方法回顾性分析2007年1月—2013年5月我院诊治的110例急性胰腺炎患者的临床资料,统计合并肝功能损害发生率,观察肝损害与性别、年龄、急性胰腺炎病情程度、类型、预后等的相关性。结果 110例患者中70例患者肝功能有不同程度的异常(63.64%);男性合并肝功能损害为60.00%,与女性的68.00%比较差异无显著性;肝功能损害患者平均年龄(55.02±12.48)岁,无肝功能损害患者平均年龄(54.12±12.56)岁,比较无显著性差异(P>0.05)。重型急性胰腺炎肝功能损害发生率为(95.00%),高于轻型急性胰腺炎肝功能损害(56.67%);胆源性胰腺炎有肝功能损害(80.00%),高于非胆源性急性胰腺炎肝功能损害(44.00%)。肝功能损害患者住院(19.12±9.56)d,长于无肝功能损害患者的住院(14.27±7.34)d(P<0.05);有肝功能损害遗留糖尿病、胰腺假性囊肿、慢性复发性胰腺炎死亡的发生率为15.71%,高于无肝功能损害的急性胰腺炎的5.00%(P<0.05)。结论急性胰腺炎所致肝损害发生率较高,与胰腺炎病情、类型有关,对预后有不良影响,应积极治疗原发病、保肝。
Objective To investigate the clinical features of acute pancreatitis and liver damage. Methods The clinical data of 110 patients with acute pancreatitis treated in our hospital from January 2007 to May 2013 were retrospectively analyzed. The incidence of liver dysfunction was statistically analyzed. The severity of liver damage and gender, age, severity of acute pancreatitis, , Prognosis and other related. Results 70 of 70 patients had different degrees of abnormal liver function (63.64%). The incidence of liver dysfunction in male was 60.00%, which was not significantly different from that of female (68.00%). The mean age of patients with liver dysfunction was 55.02 ± 12.48 ) Years old, the average age of patients without liver dysfunction (54.12 ± 12.56) years old, no significant difference (P> 0.05). The incidence of hepatic dysfunction in severe acute pancreatitis was (95.00%) higher than that in light acute pancreatitis (56.67%). The gallstone pancreatitis had liver dysfunction (80.00%), which was higher than that of non-gallstone acute Pancreatitis liver damage (44.00%). Patients with liver dysfunction were hospitalized (19.12 ± 9.56) d longer than those without liver dysfunction (14.27 ± 7.34) d (P <0.05), those with left hepatic impairment, pancreatic pseudocyst and chronic recurrent pancreatitis The incidence was 15.71%, higher than 5.00% of acute pancreatitis without liver dysfunction (P <0.05). Conclusions The incidence of liver damage caused by acute pancreatitis is high, which is related to the disease and type of pancreatitis and has an adverse effect on prognosis. Active treatment of the primary disease and liver preservation should be actively taken.