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目的:检验热力及紫外线对鼠诺如病毒（murine norovirus，MNV）的消毒效果，完善预防人诺如病毒（human norovirus，HuNV）感染的消毒措施。方法:通过半数组织培养感染剂量（median tissue culture infective dose，TCIDn 50）检测在不同温度、不同作用时间等条件下热力及紫外线对MNV的消毒效果。n 结果:MNV在4 ℃、25 ℃下可以稳定存在14 d，在37 ℃下可以维持5 d。在56 ℃下30 min、58 ℃下5 min、60 ℃下1 min作用MNV均可达到消毒效果。在距离紫外光源15 cm或30 cm处辐射7.5 min，以及在距离紫外光源1 m或2 m处辐射60 min，均可对MNV产生消毒效果。结论:通过热力及紫外线均可对MNV进行有效消毒，为消毒和灭活HuNV提供了参考方法和依据。“,”Objective:To test the disinfection effects of heating and ultraviolet on murine norovirus (MNV), so as to improve disinfection measures to prevent human norovirus (HuNV) infection.Methods:The disinfection effects of heating and ultraviolet on MNV under different temperatures, different action times and other conditions were tested by median tissue culture infective dose (TCIDn 50).n Results:MNV remained active at 4 ℃ and 25 ℃ for 14 d, or at 37 ℃ for 5 d. Effective disinfection of MNV can be achieved by heating at 56 °C for 30 min, at 58 °C for 5 min, or at 60 °C for 1 min. Irradiation of MNV for 7.5 min at a distance of 15 cm or 30 cm from the ultraviolet light source, or for 60 min at a distance of 1 m or 2 m from the ultraviolet light source generated the same disinfection effects.Conclusions:Both heating and ultraviolet had effective disinfection capability of MNV, and can provide reference methods and evidences for disinfection and inactivation of HuNV.