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目的 了解人食管癌组织中nm23基因蛋白的表达情况。方法 应用免疫组化SP法检测60例食管癌组织中nm23蛋白的表达。结呆 食管癌组织中nm23蛋白表达阳性率为58％(35/60);nm23蛋白表达与临床分期及淋巴结转移有相关性,而与病理类型和分级无关。结论 nm23蛋白的异常表达与食管癌的发生和发展有关,可作为判断预后的辅助指标。
Objective To investigate the expression of nm23 gene in human esophageal cancer tissues. Methods Immunohistochemical SP method was used to detect the expression of nm23 protein in 60 cases of esophageal cancer. The positive rate of nm23 protein expression in esophageal cancer tissues was 58% (35/60). The expression of nm23 protein was correlated with clinical stage and lymph node metastasis, but not with pathological type and grade. Conclusion The abnormal expression of nm23 protein may be related to the occurrence and development of esophageal cancer, which can be used as an auxiliary index to judge the prognosis.