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目的探讨胃液培养在早产儿早期感染诊断中的价值。方法选择2006年9月至2007年9月本院新生儿重症监护病房中有围产期感染高危因素的早产儿58例,在出生1h内行胃液培养,收集早产儿的临床及实验室资料,以是否发生早期感染为依据,将其分为感染组和非感染组,进行统计学分析。结果胃液细菌培养阳性21例(36.2%),细菌菌种以表皮葡萄球菌和大肠埃希菌为主,分别占42.9%和28.6%。感染组与非感染组相比胃液培养阳性率差异无统计学意义(P>0.05)。母亲感染与早产儿生后第1天发生胃液细菌定植显著相关(χ2=7.911,P<0.05)。结论胃液培养只反映定植状态,与早期感染的发生无明显相关性,应结合临床表现及白细胞计数、C反应蛋白等检查结果合理使用抗生素。
Objective To investigate the value of gastric juice culture in the diagnosis of early infection in premature infants. Methods From September 2006 to September 2007, 58 neonates with high risk factors for perinatal infection in neonatal intensive care unit of our hospital were enrolled in this study. Gastric fluid culture was performed within 1 hour of birth and the clinical and laboratory data of preterm infants were collected. Whether the occurrence of early infection as the basis, divided into infected and non-infected group for statistical analysis. Results The gastric bacterial culture was positive in 21 cases (36.2%). Staphylococcus aureus and Escherichia coli were the main bacterial species, accounting for 42.9% and 28.6% respectively. There were no significant differences in the positive rates of gastric juice culture between infected and non-infected groups (P> 0.05). Maternal infection was associated with gastric bacterial colonization on day 1 of preterm birth (χ 2 = 7.911, P <0.05). Conclusion Gastric fluid culture only reflects the colonization status, and has no obvious correlation with the occurrence of early infection. Antibiotics should be rationally used in combination with the clinical manifestations, leukocyte count and C-reactive protein test results.