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研究了利用二氯磷酰胆碱(PC-2Cl)以及十八烷基二甲基氯硅烷(C18)和1,6-己二异氰酸酯(HDI),将仿细胞膜磷酰胆碱(PC)基团化学接枝到盖玻片表面的三条新途径,(Ⅰ)PC-2Cl直接与玻璃表面硅羟基反应,(Ⅱ)HDI先与玻璃表面硅羟基反应、水解产生的端氨基再与PC-2Cl反应进行PC接枝,(Ⅲ)C18与玻璃表面硅羟基反应后再进行II的处理步骤。通过测定改性表面的动态接触角(DCA)和X射线光电子能谱(XPS)对改性效果进行评价。结果表明,三条途径均成功地实现了PC基团在盖玻片表面接枝改性,其中接枝HDI后再与二氯磷酰胆碱反应的途径PC接枝率较高。
The effect of phosphorylcholine (PC) -based on phosphorylcholine (PC-2Cl) and octadecyl dimethylchlorosilane (C18) and hexamethylenediisocyanate (HDI) (Ⅰ) PC-2Cl reacts directly with the silanol groups on the surface of glass, (Ⅱ) HDI reacts first with the silanol groups on the surface of the glass, then hydrolyzes the terminal amino groups with PC-2Cl The reaction is grafted with PC, and (III) C18 is reacted with the silanol group on the surface of the glass followed by the II treatment. The modification effect was evaluated by measuring the dynamic contact angle (DCA) and X-ray photoelectron spectroscopy (XPS) of the modified surface. The results showed that PC grafted onto glass coverslips was successfully modified in all three ways, and the grafting rate of PC was higher when grafted with HDI followed by dichlorophosphorylcholine.