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骨髓增生性疾病患者最常见的血小板异常是在许多生理性刺激后,富含血小板的血浆(PRP)凝集功能下降,为全面了解这类病人PRP 及全血(WB)血小板的凝集状况,作者对120例骨髓增生性疾病患者进行了评价。31例患者为特发性骨髓纤维化(IM)、32例为原发性血小板增多症(ET)、23例真性红细胞增多症(PV)、34例Ph~1阳性CML。此外,还对13例细胞毒性药物治疗停止后或脾切除术后反应性血小板增多症(RT)病人进行了检测。取肘前静脉血,用标准方法制备PRP,并分别采用光学法及阻抗测量法测定PRP 及WB 血小板凝集活性。结果显示,大多数骨髓增生性疾病患者PRP 血小板凝集活性正常或下降,而WB 血小板活性增加。在WB 中常见自发性血小板凝集(SPA),而PRP
The most common platelet abnormalities in patients with myeloproliferative disorders are the reduction in agglutination of platelet-rich plasma (PRP) after many physiological stimuli. To fully understand the agglutination of PRP and whole-blood (WB) platelets in these patients, 120 cases of myeloproliferative disease were evaluated. Thirty-one patients had idiopathic myelofibrosis (IM), 32 had essential thrombocythemia (ET), 23 had polycythemia vera (PV), and 34 had Ph-1 positive CML. In addition, 13 patients with cytotoxic drug therapy after termination or after splenectomy reactive thrombocythemia (RT) were also tested. Pre-elbow venous blood samples were prepared by standard methods of PRP and optical and impedance measurements were used to measure PRP and WB platelet aggregation activity. The results showed that PRP platelet aggregation activity was normal or decreased in most patients with myeloproliferative diseases and WB platelet activity was increased. Spontaneous platelet aggregation (SPA) is common in the WB, whereas PRP