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目的:探讨小剂量纳洛酮对治疗老年充血性心衰患者心功能的影响。方法:55例老年充血性心衰患者随机分为治疗组28例和对照组27例,对照组采用常规心衰治疗,治疗组在常规心衰治疗基础上加用纳洛酮0.4 mg静脉注射,qd。2周后观察临床疗效及相关指标的变化。结果:治疗后治疗组临床疗效总有效率89.3%,对照组为77.8%,两组比较差异有极显著性(P<0.01)。两组患者治疗后与治疗前比较,左室收缩期末内径(LVSd)、左室舒张期末内径(LVDd)及氨基末端前脑钠肽(NT-proBNP)均下降,左室射血分数(LVEF)及6 min步行距离均升高,上述指标治疗组比对照组变化更明显,差异均有显著性(P<0.05)。结论:在常规心衰治疗基础上加用小剂量纳洛酮能显著改善老年充血性心衰患者的心功能,提高临床疗效。
Objective: To investigate the effect of low-dose naloxone on cardiac function in elderly patients with congestive heart failure. Methods: A total of 55 elderly patients with congestive heart failure were randomly divided into treatment group (n = 28) and control group (n = 27). The control group was treated with conventional heart failure. The treatment group was given naloxone 0.4 mg intravenously on the basis of routine heart failure treatment, qd. After 2 weeks, the changes of clinical efficacy and related indexes were observed. Results: The total effective rate of the treatment group after treatment was 89.3%, while that of the control group was 77.8%. There was significant difference between the two groups (P <0.01). After treatment, LVSd, LVDd and NT-proBNP in both groups were decreased, LVEF, And 6 min walk distance all increased, the above indicators treatment group than the control group changes more obvious differences were significant (P <0.05). Conclusion: The addition of naloxone at low dosage on the basis of routine heart failure treatment can significantly improve the cardiac function and improve the clinical efficacy in elderly patients with congestive heart failure.