Our field investigation obtains new evidence of the later Quaternary activity and recent large earthquake ruptures of the Garzê-Yushu fault. The average left-lateral slip-rate along the fault is determined to be (12 ± 2) mm/a for the last 50000 years from both offset landforms and ages of the correlative sediments. This result is very close to the estimated average left-lateral slip-rate for the Xianshuihe fault, suggesting that the horizontal movement along the northern boundary of the Sichuan-Yunnan active tectonic block and the northeastern boundary of the Qiangtang active tectonic block has been basically harmonious during the later Quaternary period. Remains of ground ruptures of recent large earthquakes have been discovered along all 3 segments of the fault, of which, the 1896 rupture on the northwestern segment is at least 70 km long, and its corresponding earthquake could be of moment magnitude 7.3. The latest rupture on the middle segment of the fault has a length of about 180 km, and was produced by an unknown-age large earthquake that could have a moment magnitude of about 7.7. Along the southeastern segment of the fault, the latest unknown-age rupture is about 65 km long and has a maximum left-lateral coseismic displacement of 5.3 m, and its corresponding earthquake is estimated to be as large as about 7.3 of moment magnitude. Based on relevant investigation, an inference has been drawn that the later two large earthquakes probably occurred in 1854 and 1866, respectively. These demonstrate that the individual segments of the studied Garzê-Yushu fault are all able to produce large earthquakes.