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目的：探讨肿瘤坏死因子（TNF－a）、白细胞介素6（IL－6）与不同类型Guillain－Barre’综合征（GBS）发病机制的关系及临床意义。方法：采用ELISA法检测GBS组（69例）．其中AIDP组（3例）、AMAN组（38例）和其它神经系统疾病组（26例）、正常对照组（26名）的血清中TNF－α、IL－6的水平。结果：急性期AIDP组、AMAN组患者血清中TNF－α、IL-6水平明显高于两个对照组（P＜0．05），且与病情轻重显著相关。随着临床症状的恢复．其TNF－α、IL—6水平明显下降。AIDP和A-MAN患者血清中TNF－α、IL—6水平无显著差异（P＞0．05）。结论：TNF－α、IL－6在GBS免疫发病机制中可能起重要作用，但在两种不同类型GBS发病中的作用是否存在差异尚不完全清楚。
Objective: To investigate the relationship between tumor necrosis factor (TNF-a), interleukin-6 (IL-6) and the pathogenesis of different types of Guillain-Barre syndrome (GBS) Methods: The GBS group was detected by ELISA (69 cases). The levels of TNF-α and IL-6 in sera of AIDP group (3 cases), AMAN group (38 cases) and other nervous system diseases group (26 cases) and normal control group (26 cases) Results: Serum levels of TNF-α and IL-6 in AIDP group and AMAN group were significantly higher than those in two control groups (P <0.05), and were significantly correlated with severity of disease. With the recovery of clinical symptoms. The levels of TNF-α and IL-6 were significantly decreased. Serum levels of TNF-α and IL-6 in patients with AIDP and A-MAN had no significant difference (P> 0.05). CONCLUSION: TNF-α and IL-6 may play important roles in the pathogenesis of GBS. However, it is unclear whether the roles of TNF-α and IL-6 in the pathogenesis of GBS are different.