为了探讨载脂蛋白Ｅ（ａｐｏＥ）的遗传变异体与非吸烟女性肺癌易感性之间的关系，在上海市和哈尔滨市两地分别收集了非吸烟女性肺癌病例１００例和８２例，以及非吸烟的女性健康人对照９５例和８９例，应用ＰＣＲ－内切酶片段长度多态性技术（ＰＣＲ－ＲＦＬＰ），分析了白细胞ＤＮＡａｐｏＥ等位基因（ａｐｏ∈）的遗传多态性。结果显示，把突变型等位基因∈４与野生型∈３相比，虽然在上海市病例组中，ＯＲ值为０．５２（９５％ＣＩ＝０．２１～１．２９），但无显著性差异，尚待扩大样本做进一步探讨。 To investigate the relationship between genetic variants of apolipoprotein E (apoE) and lung cancer susceptibility in non-smoking women, 100 lung cancer cases and 82 non-smoking female lung cancer cases were collected in Shanghai and Harbin respectively, and non-smoking In the female healthy subjects, the genetic polymorphisms of the DNA apoE allele (apo) were analyzed by PCR-RFLP in 95 and 89 cases. The results showed that comparing the mutant allele ∈4 with the wild type ∈3, the OR value was 0.52 (95% CI = 0.21 to 1.29) in the Shanghai case group, but it was not significant. Sexual differences, still need to expand the sample for further discussion.