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用哇巴因致心律失常为模型,观察自由基清除剂亚硒酸钠(Sodium Selenate)和超氧化物歧化酶(Snperoxide dismutase,简称SOD)对哇巴因致动物中毒的影响。豚鼠300-400g体重,随机分为4组:(1)对照组,n=10,静脉注入等容积生理盐水,实验结果表明哇巴因致室早、室速、室颤和死亡的剂量分别为158.15±25.46、179.76±34.29、227.68±39.35和309.87±38.23ug/kg((?)±SD)。(2)亚硒酸钠组,n=10,实验结果表明哇巴因致室早、室速、室颤和死亡的剂量分别为192.60±26.23~*、224.84±29.42~(***)、274.88±20.14~(***)和345.69±23.51~(**)ug/kg((?)±SD)。(3) SOD组,n=8,实验结果表明哇巴
Using ouabain-induced arrhythmia as a model, the effects of sodium selenate and Snperoxide dismutase (SOD) on ouabain-induced animal poisoning were observed. Guinea pigs 300-400g body weight were randomly divided into 4 groups: (1) control group, n = 10, intravenous infusion of equal volume of saline, the experimental results show that ouabain caused early morning, ventricular tachycardia, ventricular fibrillation and death dose were 158.15±25.46, 179.76±34.29, 227.68±39.35, and 309.87±38.23 ug/kg ((?)±SD). (2) In the sodium selenite group, n=10, the experimental results showed that the doses of ouabain causing early ventricular tachycardia, ventricular tachycardia, ventricular fibrillation and death were 192.60±26.23~* and 224.84±29.42~(***), respectively. 274.88±20.14~(***) and 345.69±23.51~(**)ug/kg((?)±SD). (3) SOD group, n=8, experimental results show that ouaba